A new translocation, t(10;14)(q24;q11), in T cell neoplasia

A New Translocation , t ( 1 O ; 14 ) ( q 24 ; qll ) , in T Cell Neoplasia

Four cases of T cell neoplasia are reported: three presenting as T cell acute lymphoblastic leukemia and one presenting in the leukemic phase of a T cell lymphoma. In all cases, the cells of the leukemic clone were characterized by an identical cytogenetic abnormality. This abnormality was a unique reciprocal translocation involving chromosomes 10 and 1 4. The breakpoint in chromosome 1 4 was i...

Balanced Reciprocal Translocation t(X;1) in a Girl with Tall Stature and Primary Amenorrhea

AbstractChromosomal translocations constitute one of the most important, yet uncommon, causes of primary amenorrhea and gonadal dysgenesis. Although X-autosome translocations are frequently associated with streak gonads and clinical features of the Turner syndrome, the majority of X-autosome carriers may present with a variable phenotype, developmental delay, and recognizable X-linked syndrome ...

A new translocation, t(1;3) (p36;q21), in myelodysplastic disorders.

Brief Report LYMPHOID NEOPLASIA Translocation t(2;11) in CLL cells results in CXCR4/MAML2 fusion oncogene

Chronic lymphocytic leukemia (CLL) is the most common human leukemia representing ;30% of all leukemia cases. This disease occurs in 2 forms: aggressive and indolent; both forms are characterized by the clonal expansion of CD5-positive B lymphocytes. Genomic aberrations are detected in over 80% of CLL cases and numerous studies of lymphoid malignancies showed that chromosomal translocations oft...

Detection, Cloning, Molecular Characterization and Phylogenic Analyses of a New Primate T-Cell Lymphotropic Virus Type I in Olive Baboon